Journal of Liquid Chromatography & Related Technologies · 2000 · 27 citations · 16 references
PharmacyNutritional SciencesPharmaceutical AnalysisAnalytical ChemistryChromatographic AnalysisFood AnalysisAnalytical ChromatographyBioanalytical Method ValidationChromatographic Data AnalysisChromatographic Food AnalysisChromatographyLiquid ChromatographyChromatographic ValidationHerbal SupplementsHigh-performance Liquid ChromatographyHigh-performance Liquid Chromatography Method DevelopmentIon-pair Liquid ChromatographyRefractive Index DeterminationReverse-phase ChromatographyReverse-phase Liquid Chromatography
A reverse-phase high performance liquid chromatography (HPLC) method for the determination of glucosamine in nutritional supplements was developed and validated based on USP guidelines. Separations were performed using a MetaChem Inertsil ODS-3 column with an isocratic mobile phase consisting of 10% Methanol, 90% 0.005M octanesulfonate, pH = 2.1. Glucosamine was detected using a refractive index (RI) detector. The octanesulfonate ion pairing agent allowed for retention on a C-18 column. The method proved highly reliable with respect to standard performance characteristics. The method allows for convenient quality control in the growing nutritional supplement market.
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Alan F. Philippi, Christopher T. Leffler, Susan G. Leffler et al. · Military Medicine · 1999 · 159 citations · Full text
Pharmacokinetics of glucosamine in man.
I Setnikar, Renato Palumbo, S. Canali et al. · PubMed · 1993 · 137 citations