Phospholamban Knockout Breaks Arrhythmogenic Ca ²⁺ Waves and Suppresses Catecholaminergic Polymorphic Ventricular Tachycardia in Mice

Abstract

Our results demonstrate that despite severe sarcoplasmic reticulum Ca²⁺ leak, PLN-KO suppresses triggered activities and stress-induced VTs in a mouse model of catecholaminergic polymorphic VT. These data suggest that breaking up cell-wide propagating SCWs by enhancing Ca²⁺ sequestration represents an effective approach for suppressing Ca²⁺-triggered arrhythmias.