Genetic Variations of <i>NAT2</i> and <i>CYP2E1</i> and Isoniazid Hepatotoxicity in a Diverse Population

Abstract

No single genetic variant of NAT2 and CYP2E1 showed a significant association with isoniazid-induced hepatotoxicity in this highly heterogeneous population. There was evidence of a trend for increasing hepatotoxicity risk across the rapid, intermediate and slow acetylator groups (p = 0.08).