Identification of New Variants of Human<i>BMP15</i>Gene in a Large Cohort of Women with Premature Ovarian Failure

Abstract

We describe the significant association of heterozygous BMP15 gene variants with the POF phenotype in humans (seven of 166 patients: 4.2%; P < 0.003 vs. controls). These findings are consistent with the critical role played by BMP15 in human folliculogenesis.