Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells

Abstract

Together, these results indicate that mammalian target of rapamycin activity is essential for expansion of CD34(+) hematopoietic progenitor cells during myelopoiesis. Modulation of the mammalian target of rapamycin pathway may be of benefit in the design of new therapies to control hematologic malignancies.