The novel <i>IFNGR1</i> mutation 774del4 produces a truncated form of interferon-γ receptor 1 and has a dominant-negative effect on interferon-γ signal transduction - Concepedia

Concepedia

Publication | Open Access

The novel <i>IFNGR1</i> mutation 774del4 produces a truncated form of interferon-γ receptor 1 and has a dominant-negative effect on interferon-γ signal transduction

DOI Full Paper Access

33

Citations

24

References

2007

Year

Satoshi Okada, Nobutsune Ishikawa, Hiroshi Kawaguchi, Miyuki Tsumura, Yoshinori Ohno, Shin’ichiro Yasunaga, Motoaki Ohtsubo, Y Takihara, Masao Kobayashi

Journal of Medical Genetics

Abstract

Like the 818del4 mutation, 774del4 produces a truncated form of IFNgammaR1, which has a dominant-negative effect on IFNgamma signal transduction through altered receptor stability.

References

	Year	Citations

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