Concepedia

The synovial expression and serum levels of interleukin‐6, interleukin‐11, leukemia inhibitory factor, and oncostatin m in rheumatoid arthritis

Hideyuki Okamoto, Masahiro Yamamura, Yoshitaka Morita, Seishi Harada, Hirofumi Makino, Zensuke Ota

Arthritis & Rheumatism · 1997 · 235 citations · 45 references

DOI

Abstract

IL-6, IL-11, LIF, and OSM are all produced in large amounts at the site of disease activity, but IL-6 derived from synovial fibroblasts may be the major hormone-like mediator that induces the hepatic synthesis of acute-phase proteins in RA.

References

45

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Frank C. Arnett, Steven M. Edworthy, D. Blöch et al. · Arthritis & Rheumatism · 1988 · 19.8K citations

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Impaired immune and acute-phase responses in interleukin-6-deficient mice

Manfred Köpf, Heinz Baumann, Giulia Freer et al. · Nature · 1994 · 1.8K citations · Full text

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Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

Robert L. Jilka, Giao Hangoc, Giuseppe Girasole et al. · Science · 1992 · 1.5K citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

Frédéric Houssiau, Jean‐Pierre Devogelaer, Jo Van Damme et al. · Arthritis & Rheumatism · 1988 · 850 citations