Photoamplification and Multiple Tag Release in a Linear Peptide‐Based Array of Dithiane Adducts

Abstract

Binary encoding and amplification can be achieved in linear polypeptide-based scaffolds of photoactive dithiane adducts. QA masked sensitizer is tethered to lysine and incorporated in a peptide chain terminated with a sensitizer (see picture). When illuminated, the sensitizer induces fragmentation, thus unmasking more sensitizer and resulting in a linear domino photoamplification effect.