σ1 receptors activate astrocytes via p38 <scp>MAPK</scp> phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain

Abstract

Spinal σ1 receptors are localized in astrocytes and blockade of σ1 receptors inhibits the pathological activation of astrocytes via modulation of p-p38, which ultimately prevents the development of MA in neuropathic mice.