Concepedia

Publication | Open Access

ATM Regulates 3-Methylpurine-DNA Glycosylase and Promotes Therapeutic Resistance to Alkylating Agents

DOIFull Paper Access

70

Citations

48

References

2014

Year

Sameer Agnihotri, Kelly Burrell, Pawel Buczkowicz, Marc Remke, Brian Golbourn, Yevgen Chornenkyy, Aaron S. Gajadhar, Nestor A. Fernandez, Ian D. Clarke, Mark Barszczyk,
Cancer Discovery

Abstract

Inhibition of ATM and MPG-mediated BER cooperate to sensitize tumor cells to alkylating agents, impairing tumor growth in vitro and in vivo with no toxicity to normal cells, providing an ideal therapeutic window.

References

YearCitations

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