Pure and Applied Chemistry · 2008 · 32 citations · 43 references
Natural SciencesChemistryCatalysisInorganic ChemistryOrganic ChemistryCatalytic MechanismsHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsReaction Mechanisms1, 3-Dipolar CycloadditionAldehydesCycloaddition ReactionsNitrile Oxide CycloadditionNitrone CycloadditionTransition Metal-catalyzed Synthesis
Abstract Highly tuned, one-point binding chiral iron and ruthenium complexes selectively coordinate and activate α,β-unsaturated aldehydes and ketones toward asymmetric catalytic Diels-Alder cycloaddition reactions. Here we focus on the application of these transition-metal Lewis acids to asymmetric catalytic 1,3-dipolar cycloaddition reaction between enals and cyclic and acyclic nitrones as well as aryl nitrile oxides to give isoxazolidines and isoxazolines, respectively.
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