Bioinformatics · 2010 · 202 citations · 8 references
Life SciencesBioinformaticsMolecular BiologyGene ExpressionGene Expression AnalysisGene FunctionCell-type Specific Gene ExpressionDifferential Expression AnalysisDifferential Gene Expression AnalysisGene Expression ProfilingGene Expression AtlasesTissue Expression ProfilesTissue-specific Expression AnalysisTissue-specific Expression ProfilingTissue-specific Gene Expression
UNLABELLED: The tissue-specific genes are a group of genes whose function and expression are preferred in one or several tissues/cell types. Identification of these genes helps better understanding of tissue-gene relationship, etiology and discovery of novel tissue-specific drug targets. In this study, a statistical method is introduced to detect tissue-specific genes from more than 123 125 gene expression profiles over 107 human tissues, 67 mouse tissues and 30 rat tissues. As a result, a novel subject-specialized repository, namely the tissue-specific genes database (TiSGeD), is developed to represent the analyzed results. Auxiliary information of tissue-specific genes was also collected from biomedical literatures. AVAILABILITY: http://bioinf.xmu.edu.cn/databases/TiSGeD/index.html.
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