PatchDock and SymmDock: servers for rigid and symmetric docking

TLDR

The authors present two freely available web servers for molecular docking. PatchDock predicts protein–protein and protein–small molecule complex structures, while SymmDock predicts cyclic homomultimer structures from a monomeric unit, both accepting protein PDB codes or uploaded structures and available at http://bioinfo3d.cs.tau.ac.il. The servers’ methods are highly efficient, enabling large‑scale docking experiments.

Abstract

Here, we describe two freely available web servers for molecular docking. The PatchDock method performs structure prediction of protein-protein and protein-small molecule complexes. The SymmDock method predicts the structure of a homomultimer with cyclic symmetry given the structure of the monomeric unit. The inputs to the servers are either protein PDB codes or uploaded protein structures. The services are available at http://bioinfo3d.cs.tau.ac.il. The methods behind the servers are very efficient, allowing large-scale docking experiments.