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Effect of limited food intake on survival of mice bearing spontaneous mammary carcinoma and on the incidence of lung metastases.
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1953
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NutritionLung MetastasesStrain C3h MiceEpidemiology Of CancerPublic Health NutritionPathologyFood IntakeCaloric RestrictionExperimental NutritionObesityBody CompositionMolecular NutritionPublic HealthRadiation OncologyCancer ResearchMedical NutritionMedicineMammary GlandLimited Food IntakeMicronutrientsLung CancerSpontaneous Mammary CarcinomaCancer RiskCancer EpidemiologyBreast CancerMetabolismOncologyWestern Pattern Diet
Summary The influence of restricted food intake on the survival of mice with spontaneous mammary carcinoma was investigated in three experiments. Strain C3H mice with small single tumors were paired according to age and body weight, as well as size and location of the neoplasms. One of each pair was full-fed (13 Calories daily), the other restricted (7.4 Calories). Limitation of food intake was achieved by either proportionate reduction of all dietary components (underfeeding) or by decrease of carbohydrate only (caloric restriction). A total of 163 pairs of mice was used in the study. The average survival time of the tumor-bearing mice on the low-calorie rations was about 20 per cent longer than that of the full-fed controls. Furthermore, in two-thirds of the pairs the restricted mouse outlived its respective mate. The limitation of food intake also resulted in a decreased rate of growth of the tumors, reduced incidence of additional mammary carcinomas, and lower frequency of grossly visible metastases to the lungs.