Journal of Virology · 1991 · 218 citations · 25 references
Veterinary MedicineInfectious DiseasesVeterinary MicrobiologyImmunizationVaccinologyVirologyAnimal VirusesLive Attenuated VaccinesSwine VaccinologyVector-based VaccinesVeterinary VaccinesViral VaccinesAttenuated Virus InoculationLive Attenuated Swine VaccinesLive Vector VaccinePseudorabies VaccinationPseudorabies VaccinesVectored VaccinesViral Immunity In SwineViral Vector Immunogenicity
To investigate whether live attenuated pseudorabies virus (PRV) can be used as a vaccine vector, PRV recombinants that expressed envelope glycoprotein E1 of hog cholera virus (HCV) were generated. Pigs inoculated with these recombinants developed high levels of neutralizing antibodies against PRV and HCV and were protected against both pseudorabies and hog cholera (classical swine fever).
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