Asymmetric Desymmetrization of <i>meso</i>‐1,2‐Diols by Phosphinite Derivatives of Cinchona Alkaloids

Abstract

An effective catalyst for the asymmetric monobenzoylation of meso-1,2-diols was designed—the phosphinite derivative of cinchonine (see formula). In the presence of 30 mol % of this catalyst the monobenzoylated products were obtained with high yields and enantioselectivities.