Proceedings of the National Academy of Sciences · 1985 · 83 citations · 27 references
Histone ModificationsEgg Histone MrnaEpigenetic ChangeGeneticsHistone Gene ExpressionHistone MrnaEpigeneticsEmbryologyTranscriptional RegulationMolecular EpigeneticsDevelopmental GeneticsChromatin BiologyNuclear OrganizationEmbryonic DevelopmentGene ExpressionCell BiologyChromatin FunctionChromatinParticular Histone MrnasDevelopmental BiologyChromatin StructureChromatin RemodelingNatural SciencesEpigenomicsQualitative ChangesMedicine
There are large amounts of histone mRNA present in mouse eggs. These RNAs are rapidly degraded, as are other mRNAs, after fertilization and prior to the second cleavage. During cleavage, the histone mRNA accumulates as the embryo divides. The same sets of histone genes are expressed in eggs and embryos, although there are large qualitative differences in the amounts of particular histone mRNAs. The function of the egg histone mRNA is unknown. The amount of histone mRNA in cleaving and blastocyst embryos is probably sufficient to code for the blastocyst histone proteins.
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The transition from maternal to embryonic control in the 2-cell mouse embryo.
Gin Flach, Martin H. Johnson, Peter Braude et al. · The EMBO Journal · 1982 · 627 citations · Full text
Amplification and characterization of a β-globin gene synthesized in vitro
Tom Maniatis, Sim Gek Kee, Argiris Efstratiadis et al. · Cell · 1976 · 494 citations