Prediction of hERG potassium channel affinity by the CODESSA approach

Beware of q2!

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A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

Mark Curran, Igor Splawski, Katherine W. Timothy et al. · Cell · 1995 · 2.3K citations · Full text

Medicine, Genetics, Molecular Genetics +13

A structural basis for drug-induced long QT syndrome

John S. Mitcheson, Jun Chen, Monica Lin et al. · Proceedings of the National Academy of Sciences · 2000 · 937 citations

Medicine, Cardiology, Pharmacology +17

Toward a Pharmacophore for Drugs Inducing the Long QT Syndrome:  Insights from a CoMFA Study of HERG K⁺ Channel Blockers

Andrea Cavalli, Elisabetta Poluzzi, Fabrizio De Ponti et al. · Journal of Medicinal Chemistry · 2002 · 385 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Influence of Opioid Agonists on Cardiac Human Ether-a-go-go-related Gene K+ Currents

Alexander N. Katchman, Kelly A. McGroary, Michael J. Kilborn et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 263 citations

Medicine, Pharmacology, Pharmacotherapy +14