Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells

Anti–Interleukin-12 Antibody for Active Crohn's Disease

Peter Mannon, Ivan J. Fuss, Lloyd Mayer et al. · New England Journal of Medicine · 2004 · 854 citations · Full text

Life Sciences, Immunology, Clinical Immunology +10

Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

Theresa L. Murphy, Mark Cleveland, Peter Kulesza et al. · Molecular and Cellular Biology · 1995 · 491 citations · Full text

Life Sciences, Immunology, Pathobiology +16

Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins

Scott E. Plevy, James H. M. Gemberling, Sang Hsu et al. · Molecular and Cellular Biology · 1997 · 308 citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Cytotoxic Diterpenes from the Rhizomes of<i>Hedychium coronarium</i>

Hideji Itokawa, Hiroshi Morita, Ikuko Katou et al. · Planta Medica · 1988 · 114 citations

Life Sciences, Chemistry, Medicinal Chemistry +10

Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-κB pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis

Ajaikumar B. Kunnumakkara, Haruyo Ichikawa, Preetha Anand et al. · Molecular Cancer Therapeutics · 2008 · 71 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14