Concepedia

A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors

Elisabeth I. Heath, Keith C. Bible, Robert E. Martell, Daniel C. Adelman, Patricia LoRusso

Investigational New Drugs · 2007 · 118 citations · 7 references

DOI

Concepts

References

7

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Patrick Therasse, Susan G. Arbuck, Elizabeth A. Eisenhauer et al. · JNCI Journal of the National Cancer Institute · 2000 · 15.7K citations

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Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer.

Carsten Müller‐Tidow, R. Metzger, K. Kügler et al. · PubMed · 2001 · 119 citations

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Role of p27Kip1 and Cyclin-Dependent Kinase 2 in the Proliferation of Non-Small Cell Lung Cancer

Hidetada Kawana, Jun‐ichi Tamaru, Tomoaki Tanaka et al. · American Journal Of Pathology · 1998 · 98 citations · Full text

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Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanoma

Susan Burdette-Radoux, Richard Tozer, Reinhard Lohmann et al. · Investigational New Drugs · 2004 · 89 citations

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A Phase II Trial of Flavopiridol (NSC #649890) in Patients with Previously Untreated Metastatic Androgen-Independent Prostate Cancer

Glenn Liu, David R. Gandara, Primo N. Lara et al. · Clinical Cancer Research · 2004 · 67 citations

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