Prevalence of C282Y and H63D Mutations in the Hemochromatosis (<i>HFE</i>) Gene in the United States

Abstract

Estimates of prevalence of HFE mutations are within the expected range for non-Hispanic whites and blacks but the estimated prevalence of the C282Y mutation among Mexican-Americans is less than expected. Mutation data now need to be linked to clinically relevant indices, such as transferrin saturation level.