Concepedia

Adamantaplatensimycin: A Bioactive Analogue of Platensimycin

K. C. Nicolaou, Troy Lister, Ross M. Denton, Ana Montero, David J. Edmonds

Angewandte Chemie International Edition · 2007 · 111 citations · 8 references

DOI

Concepts

Abstract

Adamantly pursuing the bugs: The syntheses of the two enantiomers of adamantaplatensimycin ((−)-1 and (+)-1), a novel analogue of the newly discovered antibiotic platensimycin, have been achieved. Potent antibacterial action against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium has been revealed for the (−) enantiomer.

References

8

Synthesis and Activity of a New Generation of Ruthenium-Based Olefin Metathesis Catalysts Coordinated with 1,3-Dimesityl-4,5-dihydroimidazol-2-ylidene Ligands

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, , +15

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang, S.M. Soisson, Katherine Young et al. · Nature · 2006 · 815 citations

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Synthesis and Activity of Ruthenium Alkylidene Complexes Coordinated with Phosphine and N-Heterocyclic Carbene Ligands

Tina M. Trnka, John P. Morgan, Melanie S. Sanford et al. · Journal of the American Chemical Society · 2003 · 540 citations

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Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy

Sheo B. Singh, Hiranthi Jayasuriya, John G. Ondeyka et al. · Journal of the American Chemical Society · 2006 · 231 citations

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Total Synthesis of Platensimycin

K. C. Nicolaou, Ang Li, David J. Edmonds · Angewandte Chemie International Edition · 2006 · 189 citations

, , +17