Enantioselective Total Synthesis of (+)‐Milnamide A and Evidence of Its Autoxidation to (+)‐Milnamide D

Abstract

Spontaneous oxidation of the marine-sponge-derived peptide (+)-milnamide A (1) to (+)-milnamide D (2), which is also a natural product, was observed during the total synthesis of 1. The absolute configurations of the structures were determined and are also reported.