In Vivo Mechanisms of Tissue-Selective Drug Toxicity: Effects of Liver-Specific Knockout of the NADPH-Cytochrome P450 Reductase Gene on Acetaminophen Toxicity in Kidney, Lung, and Nasal Mucosa

ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. I. ROLE OF DRUG METABOLISM

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ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. II. ROLE OF COVALENT BINDING IN VIVO

David J. Jollow, John R. Mitchell, William Z. Potter et al. · Journal of Pharmacology and Experimental Therapeutics · 1973 · 1.2K citations

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Acetaminophen-Induced Hepatic Necrosis

David J. Jollow, S S Thorgeirsson, William Z. Potter et al. · Pharmacology · 2008 · 1.1K citations

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N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

David C. Dahlin, Gerald T. Miwa, Albert Lu et al. · Proceedings of the National Academy of Sciences · 1984 · 1.1K citations

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Role of CYP2E1 in the Hepatotoxicity of Acetaminophen

Susanna S.T. Lee, Jeroen Buters, Thierry Pineau et al. · Journal of Biological Chemistry · 1996 · 658 citations · Full text

Medicine, Pharmacology, Toxicology +15