Concepedia

Circadian Rhythm of Circulating Fibroblast Growth Factor 21 Is Related to Diurnal Changes in Fatty Acids in Humans

Haoyong Yu, Fuzhen Xia, Karen SL Lam, Yu Wang, Yuqian Bao, Jialiang Zhang, Yunjuan Gu, Pengcheng Zhou, Junxi Lu, Weiping Jia,

Clinical Chemistry · 2011 · 166 citations · 32 references

DOIFull text

Open access

Abstract

These findings support the role of FGF21 as an important metabolic regulator that integrates the circadian rhythm with energy homeostasis in humans. Diurnal rhythms of circulating FGF21 could be partly caused by the oscillation of free fatty acids.

References

32

FGF-21 as a novel metabolic regulator

Alexei Kharitonenkov, Tatiyana L. Shiyanova, Anja Köester et al. · Journal of Clinical Investigation · 2005 · 2.1K citations · Full text

, , +14

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Takeshi Inagaki, Paul A. Dutchak, Guixiang Zhao et al. · Cell Metabolism · 2007 · 1.5K citations · Full text

, , +11

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Michael K. Badman, Pavlos Pissios, Adam R. Kennedy et al. · Cell Metabolism · 2007 · 1.5K citations · Full text

, , +15

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

Jing Xu, David J. Lloyd, Clarence Hale et al. · Diabetes · 2008 · 1.1K citations · Full text

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

Xinmei Zhang, Dennis C.Y. Yeung, Michal Karpíšek et al. · Diabetes · 2008 · 883 citations