Involvement of Ca²⁺ ‐Calmodulin‐Dependent Protein Kinase II in the Intestinal Secretory Action of <i>Escherichia coli</i> Heat‐Stable Enterotoxin II

Abstract

Treating the mouse intestine with the calmodulin antagonist W-7 and KN-93, an inhibitor of Ca(2+)-calmodulin-dependent protein kinase II (CaMK II), reduced the sensitivity of the host to the action of Escherichia coli heat-stable enterotoxin II (STII). CaMK II activity in mouse intestinal cells increased after exposure to STII. These results indicate that CaMK II is involved in the mechanism of action of STII.