The Novel GLP-1–Gastrin Dual Agonist ZP3022 Improves Glucose Homeostasis and Increases β-Cell Mass without Affecting Islet Number in db/db Mice

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Alexandra E. Butler, Juliette Janson, Susan Bonner‐Weir et al. · Diabetes · 2003 · 4K citations

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Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Yuval Dor, Juliana Brown, Olga I. Martinez et al. · Nature · 2004 · 2.2K citations

Life Sciences, Cell Biology, Developmental Biology +14

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

Gang Xu, Doris A. Stoffers, Joel F. Habener et al. · Diabetes · 1999 · 1.2K citations

Life Sciences, Endocrinology, Physiology +16

Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study

Arne Astrup, Stephan Rössner, Luc Van Gaal et al. · The Lancet · 2009 · 1.2K citations

Agriculture, Nutritional Sciences, Pharmacology +10

Pancreatic β‐cell mass in European subjects with type 2 diabetes

J. Rahier, Yves Guiot, Rose‐Marie Goebbels et al. · Diabetes Obesity and Metabolism · 2008 · 741 citations

Medicine, Cell Biology, Endocrinology +17