An Artificial Base Pair, Mediated by Hydrogen Bonding and Metal‐Ion Binding

Abstract

Silver service: Addition of silver(I) to an oligonucleotide comprising 1-deazaadenine and thymine nucleobases leads to the formation of a Hoogsteen-type double helix with specific binding of one metal ion per base pair (see scheme). Each base pair is mediated by one hydrogen bond and by two coordination bonds.