Science · 2003 · 565 citations · 9 references
Life SciencesChemistryMolecular BiologyNucleic Acid BiochemistryNucleic Acid ChemistryStructural BiologyBase PairingDna ChemistryDna StructureNucleic Acid StructureNucleic Acid SynthesisOligonucleotide ChemistryBidentate Ligand BindingChemical Modification Of OligonucleotidesComplementary Base PairingDna Base PairingDna-based Self-assemblyNucleobase Base PairingOligonucleotide AssemblyOligonucleotide Hybridization
DNA has a structural basis to array functionalized building blocks. Here we report the synthesis of a series of artificial oligonucleotides, d(5'-GH(n)C-3') (n = 1 to 5), with hydroxypyridone nucleobases (H) as flat bidentate ligands. Right-handed double helices of the oligonucleotides, nCu2+.d(5'-GH(n)C-3')2 (n = 1 to 5), were quantitatively formed through copper ion (Cu2+)-mediated alternative base pairing (H-Cu2+-H), where the Cu2+ ions incorporated into each complex were aligned along the helix axes inside the duplexes with the Cu2+-Cu2+ distance of 3.7 +/- 0.1 angstroms. The Cu2+ ions were coupled ferromagnetically with one another through unpaired d electrons to form magnetic chains.
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A Novel Copper-Mediated DNA Base Pair
Eric Meggers, Patrick L. Holland, William B. Tolman et al. · Journal of the American Chemical Society · 2000 · 347 citations
Structure of a Copper-Mediated Base Pair in DNA
S. Atwell, Eric Meggers, Glen Spraggon et al. · Journal of the American Chemical Society · 2001 · 248 citations