Rapamycin treatment causes developmental delay, pigmentation defects, and gastrointestinal malformation on Xenopus embryogenesis

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text

Lifespan Extension, Aging, Rapamycin Fed +11

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

David A. Guertin, Deanna M. Stevens, Carson C. Thoreen et al. · Developmental Cell · 2006 · 1.4K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +8

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway

Pankaj Kapahi, Brian M. Zid, Tony Harper et al. · Current Biology · 2004 · 1.3K citations · Full text

Biology, Lifespan Extension, Longevity +6

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

Diane C. Fingar, Sofie R. Salama, Christina Tsou et al. · Genes & Development · 2002 · 1.1K citations · Full text