Concepedia

Leucine supplementation modulates fuel substrates utilization and glucose metabolism in previously obese mice

Elke Binder, Francisco J. Bermúdez‐Silva, Melissa Elie, Thierry Lesté-Lasserre, Ilaria Belluomo, Samantha Clark, Adeline Duchampt, Gilles Mithieux, Daniela Cota

Obesity · 2013 · 42 citations · 27 references

DOI

Abstract

Leucine supplementation might represent an adjuvant beneficial nutritional therapy during weight loss and maintenance, because it improves lipid and glucose metabolism and restores leptin sensitivity in previously obese animals.

References

27

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

Christopher B. Newgard, Jie An, James R. Bain et al. · Cell Metabolism · 2009 · 3.1K citations · Full text

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Metabolite profiles and the risk of developing diabetes

Thomas J. Wang, Martin G. Larson, Ramachandran S. Vasan et al. · Nature Medicine · 2011 · 3.1K citations · Full text

, , +7

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Yasuhiko Minokoshi, Young‐Bum Kim, Odile D. Peroni et al. · Nature · 2002 · 2K citations

, , +8

Hypothalamic mTOR Signaling Regulates Food Intake

Daniela Cota, Karine Proulx, Kathi A. Blake Smith et al. · Science · 2006 · 1.2K citations

, , +21

Plasma Amino Acid Levels and Insulin Secretion in Obesity

Philip Felig, Errol B. Marliss, George F. Cahill · New England Journal of Medicine · 1969 · 808 citations

, , +15