Correlation of Gingival Crevicular Fluid Interleukin‐18 and Monocyte Chemoattractant Protein‐1 Levels in Periodontal Health and Disease

Abstract

GCF IL-18 and MCP-1 concentrations increased in periodontal disease compared to health and correlated positively with the severity of disease. Further, based on the positive correlation of IL-18 and MCP-1 found in this study, it can be proposed that IL-18 may promote an inflammatory response by the induction of MCP-1 production and the subsequent recruitment and activation of circulating leukocytes at the inflammatory site.