The Journal of Experimental Medicine · 1972 · 346 citations · 13 references
Life SciencesImmunologyMicrobiologyAdaptive ImmunityCellular ImmunologyImmunology Of Infectious DiseasesAdaptive Immune ResponsesBacterial ImmunologyCell-mediated ImmunityCellular Immune ResponsesImmune Responses To InfectionT Cell BiologyAdaptive Immune Responses To BacteriaBacterial Immune ResponsesCell-mediated Antimicrobial DefenseCellular Immune Response To BacteriaT Cell Responses To Bacterial Infection
Spleen cells of mice infected with Listeria monocytogenes were adoptively transferred to normal mice. Such lymphocytes conferred resistance to a lethal challenge with Listeria. Hyperimmunization of the donor reduces the number of cells necessary to transfer effective immunity. Such spleen cells if treated with anti-theta serum do not transfer resistance to Listeria. Hence, thymus (T) lymphocytes are involved in the resistance to infection with the facultative intracellular bacteria L. monocytogenes.
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Theta Isoantigen as a Marker of Thymus-derived Lymphocytes in Mice
Martin Raff · Nature · 1969 · 446 citations
R. E. Billingham, L Brent, Peter Medawar · Proceedings of the Royal Society of London. Series B, Biological sciences · 1954 · 429 citations