“Artificial Metabolisms” for the Asymmetric One‐Pot Synthesis of Branched‐Chain Saccharides

Abstract

The renewable resources glucose, fructose, and sucrose are rendered useful sources of dihydroxyacetonephosphate (DHAP) for asymmetric aldol additions by multienzymatic reaction cascades in vitro with the rabbit muscle aldoase (FruA). In highly diastereoselective, efficient transformations with aldehydes, a series of unusual alkylated spiroannelated and branched saccharides become accessible (E = enzyme).