Exposure of HeLa cells to 06-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

Leonard C. Erickson, Laurent Guy, Nancy A. Sharkey et al. · Nature · 1980 · 311 citations

Genome Instability, Natural Sciences, Oligonucleotide +6

Methylation of the O⁶Position of Guanine in DNA is the Most Likely Initiating Event in Carcinogenesis by Methylating Agents

Anthony E. Pegg · Cancer Investigation · 1984 · 236 citations

Chromatin, Chromatin Structure, Medicine +15

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

William P. Tong, Marion Kirk, David B. Ludlum · PubMed · 1982 · 226 citations

Nucleic Acid Chemistry, Bioorganic Chemistry, Biochemistry +15

The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis

Daniel B. Yarosh · Mutation Research/DNA Repair Reports · 1985 · 222 citations

Oncogenic Agent, Epigenetic Change, Genetics +9

Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.

Tommie V. McCarthy, Peter Karran, Tomas Lindahl · The EMBO Journal · 1984 · 218 citations · Full text

Nucleic Acid Chemistry, Natural Sciences, Nucleic Acid Biochemistry +4