PLoS ONE · 2015 · 30 citations · 21 references
Veterinary MedicineInfectious Disease ControlInfectious DiseasesImmunizationInfectious Disease EpidemiologyStochastic ModelingInfectious Disease DynamicsTransmission DynamicsVaccinationVaccination PolicyVaccination SchedulesVaccine-preventable DiseasesEpidemic DemographyEpidemic ModelsEpidemic Population DynamicsInfectious Disease ModelsModeling Of Epidemic ResponseStochastic Epidemic ModelsSusceptible-infected-recovered ModelsVaccination Modeling
Developing robust, quantitative methods to optimize resource allocations in response to epidemics has the potential to save lives and minimize health care costs. In this paper, we develop and apply a computationally efficient algorithm that enables us to calculate the complete probability distribution for the final epidemic size in a stochastic Susceptible-Infected-Recovered (SIR) model. Based on these results, we determine the optimal allocations of a limited quantity of vaccine between two non-interacting populations. We compare the stochastic solution to results obtained for the traditional, deterministic SIR model. For intermediate quantities of vaccine, the deterministic model is a poor estimate of the optimal strategy for the more realistic, stochastic case.
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