Role of macrophage-derived hypoxia-inducible factor (HIF)-1α as a mediator of vascular remodelling

Abstract

Our results show that HIF-1α in macrophages plays a crucial role in promoting vascular inflammation and remodelling. As decreasing HIF-1α activity in macrophages may prevent the progression of vascular remodelling, HIF-1α may be a possible therapeutic target in vascular diseases.