Antimicrobial Agents and Chemotherapy · 2014 · 90 citations · 12 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial ResistanceBacteriologyMicrobial GeneticsAntibiotic ResistanceAntibiotic Resistance GeneticsAntibiotic Resistance MechanismsBacterial BiofilmsBacterial GeneticsResistance GenesAntibiotic Resistance GenesAntimicrobial Resistance In BiofilmsBiofilm-associated Antimicrobial ResistanceBiofilms As Resistance ReservoirsCampylobacter ResistanceResistance Gene DisseminationResistance Gene Transmission
Campylobacter jejuni is a leading food-borne pathogen, and its antibiotic resistance is of serious concern to public health worldwide. C. jejuni is naturally competent for DNA transformation and freely takes up foreign DNA harboring genetic information responsible for antibiotic resistance. In this study, we demonstrate that C. jejuni transfers antibiotic resistance genes more frequently in biofilms than in planktonic cells by natural transformation.
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Extracellular DNA Required for Bacterial Biofilm Formation
Cynthia B. Whitchurch, Tim Tolker‐Nielsen, Paula Ragas et al. · Science · 2002 · 2.2K citations