Correction of Defective Interdomain Interaction Within Ryanodine Receptor by Antioxidant Is a New Therapeutic Strategy Against Heart Failure - Concepedia

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Correction of Defective Interdomain Interaction Within Ryanodine Receptor by Antioxidant Is a New Therapeutic Strategy Against Heart Failure

120

Citations

28

References

2005

Year

Masafumi Yano, Shinichi Okuda, Tetsuro Oda, T Tokuhisa, Hiroki Tateishi, Mamoru Mochizuki, Toshiyuki Noma, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto,

Abstract

During the development of heart failure, edaravone ameliorated the defective interdomain interaction of the RyR2. This prevented Ca2+ leak and LV remodeling, leading to an improvement of cardiac function and an attenuation of LV remodeling.

References

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