Concepedia

Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis

Miguel A. Frias, U. Lang, Christine Gerber-Wicht, Richard W. James

Cardiovascular Research · 2009 · 80 citations · 31 references

DOI

Abstract

HDL and its sphingosine-1-phosphate component can protect cardiomyocytes against doxorubicin toxicity and may offer one means of reducing cardiotoxic side effects during doxorubicin therapy. The study identified anti-apoptotic pathways that could be exploited to improve cardiomyocyte survival.

References

31

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, , +16