Complete Genome Sequence and Annotation of the <i>Treponema pallidum</i> subsp. <i>pallidum</i> Chicago Strain

Abstract

In syphilis research, the Nichols strain of Treponema pallidum, isolated in 1912, has been the most widely studied. Recently, important differences among T. pallidum strains emerged; therefore, we sequenced and annotated the Chicago strain genome to facilitate and encourage the use of this strain in studying the pathogenesis of syphilis.