FUNCTIONAL ASSESSMENT OF MULTIPLE P-GLYCOPROTEIN (P-GP) PROBE SUBSTRATES: INFLUENCE OF CELL LINE AND MODULATOR CONCENTRATION ON P-GP ACTIVITY

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

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Medicine, Pharmacokinetics, Pharmacology +9

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

Kazumitsu Ueda, Noboru Okamura, Midori Hirai et al. · Journal of Biological Chemistry · 1992 · 676 citations · Full text

Medicine, Endocrinology, Pharmacology +15

Rational Use of in Vitro P-glycoprotein Assays in Drug Discovery

Joseph W. Polli, Stephen A. Wring, Joan E. Humphreys et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 662 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

Raymond Evers, Marcel Kool, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1998 · 615 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

OATP and P-Glycoprotein Transporters Mediate the Cellular Uptake and Excretion of Fexofenadine

Mirjana Cvetković, Brenda F. Leake, Martin F. Fromm et al. · Drug Metabolism and Disposition · 1999 · 595 citations

Pharmacy, Pharmacokinetics, Pharmacology +17