Journal of Epidemiology and Global Health · 2015 · 18 citations · 21 references
PharmacyPharmacotherapyClinical EpidemiologyClinical PharmacologyHealth AssessmentCardiovascular DiseaseComorbidityHealth Status MeasurementHealth-related Quality Of LifeHealth-related Quality Of Life MeasurementQuality Of LifeAdministration FrequencyAntihypertensive TreatmentBlood Pressure Adverse EffectsCase-control Study DesignDrug-related Side EffectsPsychosocial Predictors
Cardiovascular disease is a major cause of morbidity and mortality worldwide, hypertension being one of their most prevalent risk factors. Information on health related quality of life (QOL) of hypertensive individuals in Lebanon is lacking. Our objectives were to evaluate QOL of hypertensive patients compared with non-hypertensive subjects and to suggest possible predictors of QOL in Lebanon. We conducted a case control study among individuals visiting outpatient clinics. Quality of life was assessed using the eight item (SF-8) questionnaire administered face to face to the study population, applied to hypertensive (N=224) and non-hypertensive control (N=448) groups. Hypertensive patients presented lower QOL scores in all domains, particularly in case of high administration frequency and occurrence of drug related side effects. Among hypertensive patients, QOL was significantly decreased with the presence of comorbidities (β=-13.865, p=0.054), daily frequency of antihypertensive medications (β=-8.196, p<0.001), presence of drug side-effects (β=-19.262, p=0.031), older age (β=-0.548, p<0.001), female gender (β=-21.363, p=0.05), lower education (β=-22.949, p=0.006), and cigarettes smoked daily (β=-0.726, p<0.001); regular sport activity (β=23.15, p<0.001) significantly increased quality of life. These findings indicate the necessity for health professionals to take these factors into account when treating hypertensive patients, and to tackle special subgroups with attention to their deteriorated QOL.
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Stephen S Lim, Theo Vos, Abraham D Flaxman et al. · The Lancet · 2012 · 12K citations · Full text
Public Health, Chronic Disease Control, Chronic Disease Prevention +17
Functional Status and Well-being of Patients With Chronic Conditions
Anita L. Stewart · JAMA · 1989 · 1.7K citations