Concepedia

Inhibiting Spinal Neuron-Astrocytic Activation Correlates with Synergistic Analgesia of Dexmedetomidine and Ropivacaine

Huanghui Wu, Jun-Bin Yin, Ting Zhang, Yuanyuan Cui, Yu‐Lin Dong, Guozhong Chen, Wen Wang

PLoS ONE · 2014 · 18 citations · 57 references

Open access

Abstract

i.t. co-delivery of Dex and Ropi shows synergistic analgesia on the chronic inflammatory pain, in which spinal "neuron-astrocytic activation" mechanism may play an important role.

References

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Pain Medicine, Neuropathic Pain, Thermal Therapy +21

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Synaptic Plasticity, Neurophysiology, Neurotransmission +6

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Pain Medicine, Erk Kinase, Neuropathic Pain +18