Concepedia

Phenyl N-tert-Butylnitrone Down-Regulates Interleukin-1β-Stimulated Matrix Metalloproteinase-13 Gene Expression in Human Chondrocytes: Suppression of c-Jun NH2-Terminal Kinase, p38-Mitogen-Activated Protein Kinase and Activating Protein-1

Salahuddin Ahmed, Ayesha Rahman, Absar-ul Hasnain, Victor M. Goldberg, Tariq M. Haqqi

Journal of Pharmacology and Experimental Therapeutics · 2003 · 44 citations · 24 references

DOI

Concepts

References

24

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Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.

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c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

Zuoning Han, David L. Boyle, Lufen Chang et al. · Journal of Clinical Investigation · 2001 · 775 citations · Full text

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Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-jun N-terminal kinase, and nuclear factor κB: Differential regulation of collagenase 1 and collagenase 3

John A. Mengshol, Matthew P. Vincenti, Charles I. Coon et al. · Arthritis & Rheumatism · 2000 · 651 citations

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Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice

Lisa A. Neuhold, Loran M. Killar, Weiguang Zhao et al. · Journal of Clinical Investigation · 2001 · 537 citations · Full text

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