Canine degenerative myelopathy: Biochemical characterization of superoxide dismutase 1 in the first naturally occurring non-human amyotrophic lateral sclerosis model

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

D.R. Rosen, Teepu Siddique, David T. Patterson et al. · Nature · 1993 · 7K citations

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Neurological Disorder +7

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

Lucie Bruijn, Megan K. Houseweart, Shinsuke Kato et al. · Science · 1998 · 1.2K citations

Rationalization of the effects of mutations on peptide andprotein aggregation rates

Fabrizio Chiti, Massimo Stefani, Niccolò Taddei et al. · Nature · 2003 · 1.1K citations

Engineering, Protein Folding, Natural Sciences +8

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

M E Ripps, George W. Huntley, Patrick R. Hof et al. · Proceedings of the National Academy of Sciences · 1995 · 710 citations · Full text

Knockout Mouse, Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis +15

Neuroblastoma × spinal cord (NSC) hybrid cell lines resemble developing motor neurons

Neil R. Cashman, Heather D. Durham, Jan Krzysztof Blusztajn et al. · Developmental Dynamics · 1992 · 706 citations