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Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection

Karen Fitzmaurice, Danijela Petrović, Narayan Ramamurthy, Ruth Simmons, Shahzma Merani, Silvana Gaudieri, Stuart Sims, Eugene Dempsey, Elizabeth Freitas, Susan M. Lea,

Gut · 2011 · 82 citations · 35 references

DOIFull text

Open access

Abstract

It is proposed that at least part of the protective effect of HLA-A*03 results from targeting of this key epitope in a functional site: the requirement for two mutations to balance fitness and escape provides an initial host advantage. This study highlights the potential protective impact of common HLA-A alleles against persistent viruses, with important implications for HCV vaccine studies.

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