Concepedia

Circulating Brain‐Derived Neurotrophic Factor Concentrations and the Risk of Cardiovascular Disease in the Community

Bernhard M. Kaess, Sarah R. Preis, Wolfgang Lieb, Alexa Beiser, Qiong Yang, Tai C. Chen, Christian Hengstenberg, Jeanette Erdmann, Heribert Schunkert, Sudha Seshadri,

Journal of the American Heart Association · 2015 · 146 citations · 25 references

DOIFull text

Open access

Abstract

Higher serum BDNF is associated with a decreased risk of CVD and mortality. Mendelian randomization suggests a causal protective role of BDNF in the pathogenesis of CVD.

References

25

The environment and disease: association or causation?

Austin Bradford Hill · Journal of the Royal Society of Medicine · 2015 · 7.3K citations · Full text

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The Environment and Disease: Association or Causation?

Austin Bradford Hill · Proceedings of the Royal Society of Medicine · 1965 · 6.8K citations · Full text

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Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond

Michael J. Pencina, Ralph B. D' Agostino, Ralph B. D' Agostino et al. · Statistics in Medicine · 2007 · 6.2K citations · Full text

Flexible regression models with cubic splines

Sylvain Durrleman, Richard Simon · Statistics in Medicine · 1989 · 2.6K citations

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Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers

Michael Pencina, Ralph B. D’Agostino, Ewout W. Steyerberg · Statistics in Medicine · 2010 · 2.3K citations · Full text