Concepedia

Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current

Steven M. Weiss, David Benoîst, Ed White, Weiyu Teng, DA Saint

British Journal of Pharmacology · 2010 · 27 citations · 32 references

Open access

Abstract

Riluzole preferentially blocked INaP and was protective in cardiac ischaemia and reperfusion. Thus block of the persistent sodium current would be a viable method of ameliorating cardiac ischaemic and reperfusion damage.

References

32

Guide to Receptors and Channels (GRAC), 5th edition

S P H Alexander, Alistair Mathie, JA Peters · British Journal of Pharmacology · 2011 · 1.9K citations · Full text

Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties

Charles Antzelevitch, Luiz Belardinelli, Andrew C. Zygmunt et al. · Circulation · 2004 · 675 citations · Full text

Inhibition of the Sodium-Hydrogen Exchanger With Cariporide to Prevent Myocardial Infarction in High-Risk Ischemic Situations

Pierre Théroux, Bernard Chaitman, N Danchin et al. · Circulation · 2000 · 417 citations · Full text

Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine

Luiz Belardinelli · Heart · 2006 · 383 citations · Full text

Cardiac Muscle, Electrolyte Disorder, Heart Failure +17

The Na+/H+exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction11This manuscript is dedicated to the memory of Karl-Ludwig Neuhaus (1944–2000).

Uwe Zeymer, Harry Suryapranata, J P Monassier et al. · Journal of the American College of Cardiology · 2001 · 331 citations

Thrombosis, Na+/h+exchange Inhibitor Eniporide, Cardiovascular Disease +10