Toward A Highly Specific DNA Biosensor: PNA-Modified Suspended-Core Photonic Crystal Fibers

Abstract

The feasibility of a biosensor for DNA detection based on suspended-core photonic crystal fibers is investigated. The possibility of functionalization of the hole surface, which allows DNA strand binding, is demonstrated, along with the selective detection of DNA through hybridization of immobilized peptide nucleic acid probes with their full-complementary and mismatched DNA segments.